These biochemical markers could be used while TE is not available. When the APRI score reaches 1. , FibroScan) medically necessary for follow-up of primary sclerosing cholangitis, monitoring of liver function in Wilson's disease, and for distinguishing hepatic cirrhosis from non-cirrhosis in persons with hepatitis B, hepatitis Oct 23, 2018 · APRI The AST to Platelet Ratio (APRI) test is a calculator tool that inputs routine laboratory values to assess the risk for advanced fibrosis. 09 seems to have an acceptable accuracy for prediction of high portal pressure. This review evaluates the diagnostic performance of APRI and FIB-4 in chronic HBV-related liver fibrosis. The APRI score is validated in chronic viral hepatitis. Aug 2, 2025 · The resulting number is your APRI score, offering a numerical representation derived from these common lab values. Liver function tests (LFTs): an overview Liver function tests (LFTs) involve a panel of laboratory analyses performed on a single blood sample to assess the organ’s performance. AST to Platelet Ratio Index (APRI) calculator predicts fibrosis & cirrhosis in hepatitis C with APRI Score, formula, normal range & interpretation. 0 is used, the APRI has a sensitivity of 77% and a specificity of 75% for cirrhosis. 3% and 91. 66 had moderate performance with high specificity in diagnosing cirrhosis. 7 and extent Jan 5, 2024 · FIB-4 and APRI scores for progressive liver fibrosis diagnosis in children with biliary atresia Hongyu Lyu 1 Yongqin Ye 1,2 Bin Wang 1* Calculate APRI score for non-invasive liver fibrosis assessment. How to Use the APRI Calculator: A Step-by-Step Guide Ready to use the APRI Calculator? It’s as easy as pie—or at least as easy as pie after you’ve had some practice. 5 or greater, it strongly suggests the presence of advanced scarring, including significant fibrosis or cirrhosis. 0 for the APRI were used to predict who, among patients, had cirrhosis [14 - 16]. 4% for detection of fibrosis (p<0. When we compared the validity of APRI scores in diagnosing cirrhosis, we discovered that the ideal cutoff value of APRI was determined to be 3. Oct 3, 2024 · The APRI score calculator simplifies the process of estimating liver fibrosis severity, making it a valuable tool in clinical practice for managing patients with chronic liver diseases. An APRI score of ≥1. APRI is a fair, bedside, cost-effective parameter for diagnosis of high portal pressure in patients with cirrhosis. Patients were divided into two groups based on their 2-year native liver Jan 1, 2016 · Usefulness of this marker seems to depend on the etiology of liver damage. The APRI score ranges from 0. A lower score indicates less liver scarring, while a higher score suggests more significant fibrosis or cirrhosis. Calculator: Aspartate aminotransferase (AST) to platelet ratio index (APRI) in adults (conventional units)* To continue reading this article, you must sign in with your personal, hospital, or group practice subscription. The balance between sensitivity (Se) and specificity (Sp) for a particular value of the test to rule out or rule in the patients of interest was obtained from the coordinates of the curve. The first score measures liver stiffness and the second score measures liver fat. There are several risk scores out you may have heard about such as FIB-4 (Fibrosis-4), APRI (AST to platelet ratio index), and NFS (NAFLD fibrosis score). APRI calculator requires AST, AST upper limit of normal range and platelet count. Based on the available data from the scientific literature, a cut-off value of 3. Jan 16, 2024 · To validate APRI as predictor score for severity of dengue fever, so that catastrophic events could be prevented, and early triage can save lives. ROC curves assessed the performance of APRI score in predicting SF. Liver Biopsy is needed for accurate diagnosis/staging, and before drug-therapy. | Drlogy APRI (aspartate aminotransferase [AST]-to-platelet ratio index) is recommended as the preferred non-invasive test (NIT) to assess for the presence of cirrhosis (APRI score >2 in adults) in resource-limited settings. We would like to show you a description here but the site won’t allow us. The objective of the Mar 25, 2025 · Explanation APRI Score Calculation Example: The APRI (AST to Platelet Ratio Index) score is a non-invasive marker used to assess the degree of liver fibrosis. Persons with Read the article below to find out more about NAFLD, the NAFLD score formula and the NAFLD score interpretation. The current guidelines thus respond to the Ministry of Health’s need to improve skills of health care providers as well as the quality of care and treatment offered in both public and private health facilities countrywide Jan 8, 2021 · The predictive potential of the combined APRI/ALBI score for clinically relevant outcomes such as mortality was demonstrated. May 12, 2025 · Predictive capability of aspartate transaminase-to-platelet ratio index (APRI) in assessing liver fibrosis/cirrhosis. Data of 530 consecutive patients undergoing robotic hepatectomy were analyzed. APRI SCORING is An easy way to detect Liver Cirrhosis from two simple blood tests : cbc and LFTs. Oct 1, 2017 · A SF was defined according to Metavir score (≥ F2). 5), the greater the positive predictive value and ability to rule in cirrhosis. However, the specific interpretation of a "high" APRI score may vary depending on the medical context, and a healthcare professional is best suited to evaluate the score and provide appropriate guidance and treatment. In patients with NAFLD: TE nor APRI nor FIB-4 are reliable enough to diagnose cirrhosis In populations with high prevalence of cirrhosis (subspecialty clinic) MR Elastography is superior to TE to diagnose cirrhosis in NAFLD (less “False Positives”). An evidence-based smartphone application will allow clinical translation and facilitation of risk assessment before hepatic resection using routine laboratory parameters. It is essential to refer to the specific reference range provided by the testing facility for accurate APRI score calculation. 25 for the FIB-4 and 2. . 5%) out of 200 patients in the experimental and validation groups, re-spectively. It is calculated using the formula APRI = (AST / ULN) / PLT * 100, where AST is the Aspartate Aminotransferase level, ULN is the Upper Limit of Normal AST, and PLT is the platelet count. 5 and 1. Dec 1, 2021 · The normal AST:ALT ratio is less than 1, so a score greater than 1 is suggestive of advanced fibrosis or cirrhosis. Enter AST, ULN, and platelet values to get instant screening results for chronic liver disease. If your score is less than or equal to 0. However, the combination of tests within a LFT panel may differ between laboratories and regions. 0 or higher, with a higher score indicating more advanced fibrosis. 5 are considered intermediate or indeterminate, meaning the patient may have moderate scarring, but the score alone is less definitive. Diagnostic performance of APRI and FIB-4 score was measured by area under the receiver operating characteristic (ROC) curve. Conclusions APRI correlates fairly with HVPG in patients of cirrhosis. Why is APRI important? APRI is important because it provides a non-invasive method to estimate the level of liver fibrosis. 7% and a specificity of 62. APRI score measures the extent of fibrosis in the liver. The APRI Calculator takes these two values, does a bit of mathematical magic, and gives you a score that can help determine the extent of liver damage. Non-invasive serum markers for assessing liver fibrosis stage currently available in Australia Method Formula Key threshold for excluding cirrhosis* APRI APRI = (AST [IU/L] ÷ AST ULN [IU/L] × 100) ÷ platelet count ( × 109/L) Online calculator APRI < 1. Medical Necessity Aetna considers transient elastography (e. Alternative techniques such as acoustic radiation impulse Supplementary tables Supplementary Table 1. (FIB-4) calculator requires Age, AST, Platelet count and ALT. Interpreting Your APRI Score Results Interpreting your APRI score involves understanding different ranges and what they generally suggest about liver fibrosis. APRI: — Interpretation: — Enter AST, ULN, and platelets; the score updates automatically. Apr 11, 2024 · Abstract. Both scores show strong correlations with histological findings and serve as effective tools for diagnosing significant fibrosis and We would like to show you a description here but the site won’t allow us. Mar 28, 2025 · Objective To explore the value of preoperative Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) and Fibrosis-4 score (FIB-4) in predicting short-term prognosis of children with biliary atresia (BA) undergoing Kasai portoenterostomy (KPE). Clinical Pearls 💡 APRI is most useful in patients with elevated liver enzymes 💡 Scores >1. 01). 05 are shown in table I. Patients with APRI scores in this range may require further evaluation, monitoring, and additional diagnostic tests to assess the extent of fibrosis. FIB-4 is the most used, so let’s do a deep dive into its origins… The spectrum of liver disease in persons with CHB ranges from minimal fibrosis to cirrhosis and HCC. 2 Jan 7, 2022 · Non-alcoholic fatty liver disease (NAFLD) is the term used to encompass a range of conditions from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to fibrosis and lead Mar 24, 2025 · Results: In the multiple linear regression models, ALT and AST APRI scores were associated with fasting blood glucose after adjusting various potential confounders in the whole population or subgroup analysis (all P < 0. The APRI score indicates the level of fibrosis in the liver, with higher scores indicating more severe fibrosis. 0 had a sensitivity of 76% and specificity of 72% for predicting cirrhosis. 5. The APRI score has no universal cut-off values, as it is not sufficiently sensitive to rule out significant diseases (especially with midrange values). Assess likelihood of fibrosis or cirrhosis non-invasively using AST and platelet count. This study aims to evaluate the correlation between APRI scores and perioperative outcomes following robotic hepatectomy. g. 5 calls for clinical evaluation so as to make a better decision concerning treatment. 0 FIB-4 FIB-4 = (age [years] × AST [U/L]) ÷ (platelet count [× 109/L] × √ALT [U/L]) Online This review evaluates the diagnostic performance of APRI and FIB-4 in chronic HBV-related liver fibrosis. We sought to investigate the Policy Scope of Policy This Clinical Policy Bulletin addresses non-invasive tests for hepatic fibrosis. [21, 22] The aspartate aminotransferase to platelet ratio index (APRI) is also an acceptable alternative for identifying significant fibrosis in people with Jun 28, 2018 · Background and aim The aspartate aminotransferase (AST)-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) are commonly used compound surrogates for advanced fibrosis in chronic hepatitis C (CHC) patients. 5, your liver is either completely free of fibrosis or has a tiny bit Aug 2, 2025 · Interpreting your APRI score involves understanding different ranges and what they generally suggest about liver fibrosis. The NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score estimates amount of scarring in the liver based on several laboratory tests. 5), the greater the negative predictive value (and ability to rule out cirrhosis) and the higher the value (greater than 1. An APRI score greater than 1 has a sensitivity of 76% and specificity of 72% for predicting cirrhosis. However, the use of APRI and FIB-4 entails a risk of overestimating the fibrosis stage due to the impact of necroinflammatory activity on transaminases. The aspartate transaminase to platelet ratio index (APRI) has been proposed as an easy-to-use biochemical marker in obese adults with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatotic hepatitis (NASH). The APRI score can help determine the fibrosis stage in liver-related conditions. Receiver operating characteristic (ROC) curves were used for assessing the ability of the APRI as a predictor of the absence or presence of liver fibrosis (fibrosis score of 0 vs fibrosis scores of 1-4). In patients with CHC, the APRI showed a sensitivity of 72. Compensated cirrhosis may progress over time to decompensated cirrhosis, which is associated with the potentially life-threatening complications of ascites and spontaneous bacterial peritonitis, oesophageal varices and bleeding, hepatic encephalopathy, sepsis and renal failure. Apr 8, 2025 · Figures 2–4 present the median and interquartile ranges (25th–75th percentiles) of FibroScan, APRI, and FIB-4 scores across the entire cohort and subgroups, including alcoholic patients, diabetic/obese patients, and those with chronic hepatitis B and/or C. Most experts recommend using 40 IU/L as the value for the AST upper limit of normal when calculating an APRI value. You can learn more about AST, ALT and Platelet count blood tests The AST to Platelet Ratio Index (APRI) tool has been found to useful as a non-invasive index that correlates with liver biopsy findings of fibrosis and cirrhosis. 05, liver biopsy diagnosed advanced fibrosis staging (F3 and F4) in only 16 (8%) and 23 (11. Jan 24, 2023 · Given fibrosis has shown to correlate with malignancy and the aminotransferase-platelet ratio index (APRI) score, a marker for hepatic fibrosis, has shown to be useful in prognosticating hepatocellular carcinoma, this study aimed to assess the utility of APRI score in prognosticating post-surgical outcomes in CCA patients. It is highly recommended to ask your doctor about these calculators and their potential significance regarding the health of your liver. The APRI score correlates significantly to fibrosis stage in patients with chronic hepatitis C. Table 1 outlines the most common markers used in LFTs in New Zealand and their biological significance. The lower the APRI score (<0. Persons with It is essential to refer to the specific reference range provided by the testing facility for accurate APRI score calculation. 5 in the normal range; hence, any score below 0. 5 or over 1. Common cutoffs Supplementary tables Supplementary Table 1. Transient elastography (e. APRI (aspartate aminotransferase [AST]-to-platelet ratio index) is recommended as the preferred non-invasive test (NIT) to assess for the presence of cirrhosis (APRI score >2 in adults) in resource-limited settings. Assess the likelihood of cirrhosis in Hepatitis C patients using the APRI score, a reliable diagnostic tool. APRI score 0. 05). Results The concordance and discordance between APRI Score and liver biopsy for a cutoff value of 1. 99, with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 33%, 86%, 70%, and 56%, respectively. 0 FIB-4 FIB-4 = (age [years] × AST [U/L]) ÷ (platelet count [× 109/L] × √ALT [U/L]) Online The 2015 edition of the National Guidelines for the prevention and management of Viral Hepatitis B and C were developed in line with the recently published WHO guidelines. Evaluate AST levels and platelet count to predict fibrosis stages in chronic liver disease. 5: Falling within this range suggests an intermediate probability of significant fibrosis. This AST to Platelet Ratio Index APRI calculator computes the APRI score based on the platelet count and AST value to check for cirrhosis signs. When a cut off of >1. Studies indicate that while APRI is valued for its simplicity, FIB-4 demonstrates superior sensitivity and specificity, particularly in older populations. APRI Score is an easy, low cost and practice alternative method which was described as an alternative for assessing structural changes in chronic hepatitis C (CHC). The APRI does not report on the differing stages of fibrosis. 8%, respectively, while the sensitivity and specificity of FIB-4 were 41. The APRI score usually ranges between 0. 5) the greater the positive predictive value (and ability to rule in cirrhosis); midrange values are less helpful. 5), the greater the negative predictive value and ability to rule out cirrhosis. The APRI score was calculated according to the formula:APRI = [ (AST/ULN) × 100] /platelet count 10 9 /L. APRI and FIB-4 scores are the most commonly used scoring systems to predict liver fibrosis. Nov 15, 2025 · This score has been shown to have reasonable performance in differentiating mild (stages 0–1) from more advanced (stages 3–4) fibrosis in chronic hepatitis B that is not being treated. The ULN for AST and ALT were taken as 40 U/L while the normal platelet count range was taken as 150,000 to 450,000/mm 3. [5] The “fibrosis index based on 5 factors” (FIB-5) is a scoring system that has just started to be used and needs more study in patients with CHB. Liver fibrosis is the common pathway from various chronic liver diseases and its progression leads to cirrhosis which carries a significant risk FibroScan works similarly to an ultrasound, emitting a small pulse of energy, called a shear wave. Diabetic/obese patients showed lower APRI, FIB-4, and liver stiffness (EKPa) values The spectrum of liver disease in persons with CHB ranges from minimal fibrosis to cirrhosis and HCC. FibroScan) or FibroTest may be the preferred NITs in settings where they are available and cost is not a major constraint. In our analysis, we conducted separate analyses using the higher and lower scores and they did not influence the performance of the test. Oct 1, 2024 · There are two numbers to keep in mind to understand your APRI score: 0. It calculates a score based on the AST (Aspartate Aminotransferase) level and platelet count from a blood test. If you are interested in other calculators related to the liver disease, check the MELD calculator (Model for End-Stage Liver Disease), FIB-4 calculator, and APRI calculator (AST to Platelet Ratio Index). The AST to Platelet Ratio Index (APRI) determines the likelihood of hepatic fibrosis and cirrhosis in patients with Hepatitis C. Both scores show strong correlations with histological findings and serve as effective tools for diagnosing significant fibrosis and May 25, 2020 · APRI score ≥ 1 and FIB-4 score ≥ 1. The noninvasive quantitation of liver stiffness (LS) by ultrasound based transient elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely liver cirrhosis. 5 strongly suggest advanced fibrosis requiring hepatology referral 💡 Consider elastography (FibroScan) for indeterminate scores 💡 Monitor trends over time rather than single measurements 💡 Combine with other non-invasive markers for better Jun 1, 2017 · Usefulness of this marker seems to depend on the etiology of liver damage. Jun 12, 2025 · APRI Score Calculator (Auto) APRI Score Calculator Formula: APRI = (AST ÷ ULN) × 100 ÷ Platelets (10⁹/L). The predictive accuracy of APRI for significant fibrosis and cirrhosis was tested by the areas under the receiver operating characteristic curves (AUROC). 0%, respectively. 5 - 1. What are the alternatives to APRI? Alternatives to APRI include FIB-4 and ELF, each with their own pros and cons. We estimated PLB cost of 60 Dollars in our institution. Lower cut-off values for APRI and FIB-4 showed similar performance. Jul 21, 2025 · Use the APRI calculator to assess liver fibrosis or cirrhosis risk. Oct 8, 2025 · APRI Score is a simple, noninvasive tool used to assess liver fibrosis and cirrhosis using routine blood tests, helping reduce the need for liver biopsy. The lower the APRI score (less than 0. Sep 30, 2023 · The sensitivity and specificity of APRI at the time of cirrhosis diagnosis were 9. The FIB-4 and APRI scores were calculated for each patient and the values obtained were rounded to two decimal places. Methods Clinical data from children who underwent KPE were analyzed. The speed of the shear wave is measured as it travels through your liver, generating two scores to determine overall liver health. The APRI Score will appear in the oval on the far right (highlighted in yellow). The AST to Platelet Ratio Index (APRI score) is an easy-to-use score to predict liver fibrosis18, such as other noninvasive serum markers (FIB-4 index, FLI, NFS, BARD, Forns index19). In a meta-analysis by Lin et al, it was found that in patients with hepatitis C, an APRI score greater than 1. 1 to 2. AST (U/L) AST Upper Limit of Normal (ULN, U/L) Platelets ×10⁹/L ×10³/µL Note: ×10³/µL is numerically equivalent to ×10⁹/L (no conversion needed). Regular monitoring of APRI scores helps track fibrosis progression and the effectiveness of treatments in individuals with liver diseases. In those cases, one investigator (SC) blinded to the patient’s historical data used the elements of the report to assign a METAVIR score range. The Fibrosis-4 (FIB-4) Index for Liver Fibrosis is a non-invasive scoring system based on several laboratory tests that help to estimate the amount of scarring in the liver. 3% and 98. Scores between 0. While the term The APRI (AST to Platelet Ratio Index) score is a non-invasive tool used to assess liver fibrosis severity. Jul 6, 2025 · Calculate the APRI Score to non-invasively assess the degree of liver fibrosis in patients with chronic liver disease, particularly hepatitis C. The Aspartate Aminotransferase to Platelet Ratio Index (APRI) score is a non-invasive tool used to assess liver fibrosis, particularly in patients with chronic hepatitis C virus (HCV) infection. When the APRI Score was lower than 1. Patients were classified based on an APRI score threshold of 0. The higher the value (>1. ALT APRI score was superior to AST APRI score in the discrimination of hyperglycemic participants. APRI, FIB-4, and FIB-5 scores of patients who underwent liver biopsy due to CHB were calculated by means of calculators and recorded to be compared with liver biopsies in terms of fibrosis scoring.

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